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NFmoc - Amino acid

Aldehyde - Aryl
halide

Amine - Azide
 

Aldehyde - Carboxylic acid

Carboxylic acid - Ester
 

Other classes include:


Carboxylic acid - Aryl halide ( / feasible)
N-Boc-Amino acid ( / feasible)
NCbz-Amino acid ( / feasible)
Carboxylic acid - Isothiocyanate ( / feasible)
Aldehyde - N-Boc-Amine ( / feasible)
Aldehyde - Sulfonyl halide ( / feasible)
Amine - Ester ( / feasible)
Azide - Sulfonyl halide ( / feasible)
Amine - N-benzyl amine ( / feasible)
Amine - N-Boc-Amine ( / feasible)
Amine - N-Cbz-amine ( / feasible)
Amine - N-Fmoc-amine ( / feasible)
Ester - Isocyanate ( / feasible)
Ester - Sulfonyl halide ( / feasible)
Functional boronates ( / feasible)
Carboxylic acid - Terminal Alkyne ( / feasible)
Carboxylic acid - Nitro ( / feasible)
Aldehyde - Ester ( / feasible)
Aldehyde - Nitro ( / feasible)
Aldehyde - Azide ( / feasible)
Azide - Aryl halide ( / feasible)
Amine - Aryl halide ( / feasible)
Aryl halide - Terminal Alkyne ()
Aryl halide - Aryl halide ()

Trifunctional DEL-compatible scaffolds

Carboxylic acid - Aldehyde - Aryl halide

Aldehyde - NBoc-Amine - Ester

Ester - Boc-Amino acid

EDF在线老虎机Amine - NBoc-Amine - Ester

NBoc - N'Fmoc - Diamino acid

Terminal Alkyne - NFmoc-Amino acid

Other classes include:


Carboxylic acid - Aldehyde - Nitro ( / feasible)
Carboxylic acid - Aryl halide - Ester ( / feasible)
Carboxylic acid - Aryl halide - Nitro ( / feasible)
Carboxylic acid - Ester - Nitro ( / feasible)
Amine - Aryl halide - Nitro ( / feasible)
Terminal Alkyne - N-Boc-amino acid ( / feasible)
Aryl halide - N-Boc-amino acid ( / feasible)
Nitro - N-Boc-amino acid ( / feasible)
N-Boc-N'-Cbz-diamino acid ( / feasible)
Aryl halide - N-Fmoc-amino acid ( / feasible)
Ester - N-Fmoc-amino acid ( / feasible)
Nitro - N-Fmoc-amino acid ( / feasible)
Amine - N-Boc-Amine - Aryl halide ( / feasible)
Amine - Aryl halide - Aryl halide ()
Aryl halide - Aryl halide - Aryl halide ()
Carboxylic acid - Aryl halide - Aryl halide ()

The current virtual database includes 175 thousand of bifunctional and 7。5 thousand of trifunctional building blocks。 All molecules in this space are feasible for synthesis with high predicted success rate, since their enumeration is based on previously acquired validated experimental data。 Additionally, custom synthesis of specific core-structures for the Customer’s needs are also possible and could be performed on both FFS and FTE base。 Our team of experienced Synthetic Organic Chemists can deliver new desired molecules at competitive prices in short lead time。

The on-DNA synthesis of functionally diverse pyridazines based on inverse-electron-demand Diels-Alder (IEDDA) reactions of 1,2,4,5-tetrazines has been shown recently. Herein we propose tetrazine-derived compound library designed for DNA ligation and DNA-compatible IEDDA reactions. See also: "Structurally optimized tetrazines for rapid biological labeling"

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