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Natural Product-like Fragments

EDF在线老虎机Source of biologically validated starting points

EDF在线老虎机4 160 compounds

Screening of natural products has inspired discovery of remarkable number of drugs。 Enrichment of small libraries with compounds possessing structural motifs validated by nature allows reaching better molecular profile and improves biological response。 A special place in drug development should belong to Natural Product-like Fragments as promising starting points within attractive chemicals space。

Key features

  • Scaffold Tree approach was applied to the Universal Natural Product Database (UNPD) comprising over 200K compounds to extract initial Scaffold Set.
  • MedChem structural filters and refinements were used in order to remove trivial chemotypes, PAINS and overpopulated cores resulting in the Reference Scaffold Set with 550 structures.
  • Substructure and similarity searches were applied to extract compounds bearing natural-like cores and moieties. Scaffold frequency analysis was carried out to finalize and optimize fragment library.
Catalog ID
Compounds
Plates
Amount
Format
Price

Catalog ID

NPL-4160-Y-10

Compounds

4 160

Plates

13

Amount

10 µL of 10 mM DMSO stock solutions

Plates and formats

384-well microplates, 320 compounds per plate, first two and last two columns empty

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Catalog ID

NPL-4160-X-50

Compounds

4 160

Plates

52

Amount

50 µL of 100 mM DMSO stock solutions

Plates and formats

96-well plates, Greiner, first and last columns empty

EDF在线老虎机Request a quote

Request a quote

Catalog ID

NPL-4160-X-100

Compounds

4 160

Plates

52

Amount

100 µL of 10 mM DMSO stock solutions

Plates and formats

96-well microplates, 80 compounds per plate

Request a quote

Request a quote

Please request for any other options through our contact form. We will be happy to deliver our library in any convenient for your project formats.

Examples of the molecules

Vindoline


Ajmaline


Omacetaxine mepesuccinate

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